Complex translocation versus independent abnormalities in chronic myeloid leukemia (Juan Ramon Gonzalez Garcia, 18 June 2012)
Reyna Lucia Barajas Torres and Juan Ramon Gonzalez...
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Comment on: Yokota et al. Molecular Cytogenetics, 5:20
Correction of proband's karyotype. (Emmanouil Manolakos, 06 June 2011)
In the Results section: The karyotype of the proband was defined as follows: 46,XY.ish der(15)(15pter->15q11.2::22q11.2->22qter)t(15;22)(q11.2;q11.2)mat(TUPLE-,TBX1-).
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Full Steam Ahead – The Unsinkable Journey of Interphase Cytogenetics.
Usually, I do not submit comments on review articles. Thus, I hope you forgive me, if this comment turns out to be a bit too wordy. Yet, it’s my great pleasure to bring to your attention this review article describing the present state of interphase cytogenetics and recent developments in the field. The BMC - Molecular Cytogenetics article summarizes relevant developments in interphase analysis from the dark days of interphase cytogenetics (the 1980’ies), when only few probes and techniques in more-or-less-in-their infancy existed to the present state. Quite frankly, Dr. SG Vorsanova and her colleagues, Drs. YB Yorov and IY Iourov, did no less than an outstanding job in providing an...
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From the proof of concept to the application (Alain Bernheim, 30 April 2009)
This superb paper clearly demonstrates a condensation asymetry between R and G bands that are intimely linked to the functionnal structure of the genome. It shows also that chromosome banding and sequence are not mathematicaly linked. There is a need to address the exact localization and spliting of tiling probes (BAC or smaller) on human genomes (male and female) to assign each bit of the complete sequence to the metaphasic and interphasic chromosomes in detail. This huge project is technically feasible via a consortium. But will be a scientific mobilisation ?
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Complex translocation versus independent abnormalities in chronic myeloid leukemia (Juan Ramon Gonzalez Garcia, 18 June 2012)
Reyna Lucia Barajas Torres and Juan Ramon Gonzalez... read full comment
Comment on: Yokota et al. Molecular Cytogenetics, 5:20
Correction of proband's karyotype. (Emmanouil Manolakos, 06 June 2011)
In the Results section: The karyotype of the proband was defined as follows: 46,XY.ish der(15)(15pter->15q11.2::22q11.2->22qter)t(15;22)(q11.2;q11.2)mat(TUPLE-,TBX1-). read full comment
Comment on: Manolakos et al. Molecular Cytogenetics, 4:6
Correction to typographical error (Michael B. Petersen, 06 March 2010)
"We apologize for the typographical error in the cited reference [5] in the published manuscript. "Mattina T, Concetta SP, Grossfeld P: Jacobsen syndrome. Orphanet J Rare Dis 2009, 4:9" should read "Mattina T, CS Perrotta, Grossfeld P: Jacobsen syndrome. Orphanet J Rare Dis 2009, 4:9" read full comment
Comment on: Manolakos et al. Molecular Cytogenetics, 2:26
Full Steam Ahead (H.-Ulli Weier, 06 March 2010)
Full Steam Ahead – The Unsinkable Journey of Interphase Cytogenetics.
Usually, I do not submit comments on review articles. Thus, I hope you forgive me, if this comment turns out to be a bit too wordy. Yet, it’s my great pleasure to bring to your attention this review article describing the present state of interphase cytogenetics and recent developments in the field.
The BMC - Molecular Cytogenetics article summarizes relevant developments in interphase analysis from the dark days of interphase cytogenetics (the 1980’ies), when only few probes and techniques in more-or-less-in-their infancy existed to the present state. Quite frankly, Dr. SG Vorsanova and her colleagues, Drs. YB Yorov and IY Iourov, did no less than an outstanding job in providing an... read full comment
Comment on: Vorsanova et al. Molecular Cytogenetics, 3:1
From the proof of concept to the application (Alain Bernheim, 30 April 2009)
This superb paper clearly demonstrates a condensation asymetry between R and G bands that are intimely linked to the functionnal structure of the genome. It shows also that chromosome banding and sequence are not mathematicaly linked.
There is a need to address the exact localization and spliting of tiling probes (BAC or smaller) on human genomes (male and female) to assign each bit of the complete sequence to the metaphasic and interphasic chromosomes in detail. This huge project is technically feasible via a consortium. But will be a scientific mobilisation ?
read full comment
Comment on: Kosyakova et al. Molecular Cytogenetics, 2:4