Table 1 |
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|
Cases with Alterations of Clinical Significance Identified by BAC and Oligo aCGH. |
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|
Pt. # |
Chr |
Band |
Start pos. |
End pos. |
Gain/Loss |
Size |
# of BACs |
# of Oligos |
|
|
||||||||
|
21637 |
chr16 |
p11.2 |
29,563,985 |
30,066,187 |
Loss |
502,202 |
5 |
46 |
|
|
||||||||
|
21992 |
chr16 |
p11.2 |
29,563,985 |
30,066,187 |
Loss |
502,202 |
5 |
46 |
|
|
||||||||
|
22013 |
chr16 |
p11.2 |
29,563,985 |
30,066,187 |
Loss |
502,202 |
5 |
46 |
|
|
||||||||
|
21993 |
chr10 |
q25.2q25.3 |
114,306,207 |
114,925,368 |
Loss |
619,161 |
3 |
36 |
|
|
||||||||
|
21756 |
chr2 |
q35 |
219,418,281 |
220,060,969 |
Loss |
642,688 |
2 |
43 |
|
|
||||||||
|
22002 |
chr2 |
q37.3 |
239,664,393 |
240,400,008 |
Loss |
735,615 |
3 |
82 |
|
|
||||||||
|
22334 |
chr10 |
q25.2q25.3 |
114,024,053 |
115,677,301 |
Gain |
1,653,248 |
3 |
53 |
|
|
||||||||
|
21688 |
chr16 |
p13.11p12.3 |
15,056,257 |
16,742,812 |
Gain |
1,686,555 |
3 |
61 |
|
|
||||||||
|
21667 |
chr17 |
p12 |
14,052,297 |
15,742,271 |
Gain |
1,689,974 |
3 |
67 |
|
21896 |
chr4 |
q35.2 |
189,407,487 |
191,133,809 |
Loss |
1,726,322 |
8 |
147 |
|
|
||||||||
|
22269 |
chr2 |
q12.3q13 |
107,945,041 |
109,784,684 |
Loss |
1,839,643 |
6 |
102 |
|
|
||||||||
|
21640 |
chr19 |
q13.42 |
59,272,450 |
61,239,237 |
Gain |
1,966,787 |
8 |
135 |
|
|
||||||||
|
22117 |
chr9 |
q33.1 |
118,991,777 |
121,063,590 |
Gain |
2,071,813 |
3 |
67 |
|
|
||||||||
|
22066 |
chr8 |
p12p11.21 |
38,303,146 |
40,515,492 |
Gain |
2,212,346 |
6 |
104 |
|
|
||||||||
|
21786 |
chr1 |
q21.1 |
144,973,942 |
147,421,814 |
Gain |
2,447,872 |
5 |
63 |
|
|
||||||||
|
22237 |
chr1 |
q21.1 |
144,973,942 |
147,421,814 |
Gain |
2,447,872 |
5 |
63 |
|
|
||||||||
|
22310 |
chr22 |
q11.21 |
17,299,742 |
19,770,655 |
Loss |
2,470,913 |
13 |
205 |
|
|
||||||||
|
22050 |
chr22 |
q11.21 |
17,007,819 |
19,770,655 |
Loss |
2,762,836 |
13 |
208 |
|
|
||||||||
|
21936 |
chr1 |
q21.1 |
144,973,942 |
147,966,185 |
Gain |
2,992,243 |
5 |
65 |
|
|
||||||||
|
21719 |
chr2 |
q31.1 |
169,823,689 |
172,870,083 |
Loss |
3,046,394 |
8 |
119 |
|
|
||||||||
|
22128 |
chr4 |
q34.3 |
179,065,989 |
182,435,119 |
Loss |
3,369,130 |
3 |
91 |
|
|
||||||||
|
22006 |
chr17 |
p11.2 |
16,723,071 |
20,145,604 |
Loss |
3,422,533 |
18 |
311 |
|
|
||||||||
|
22174 |
chr1 |
q41q42.12 |
221,260,860 |
224,709,317 |
Loss |
3,448,457 |
9 |
178 |
|
|
||||||||
|
21971 |
chr22 |
q11.23q12.2 |
24,025,269 |
28,008,109 |
Loss |
3,982,840 |
3 |
111 |
|
|
||||||||
|
22073 |
chr15 |
q11.2q13.1 |
21,208,177 |
26,194,049 |
Loss |
4,985,872 |
11 |
281 |
|
|
||||||||
|
21687 |
chr16 |
q12.2q21 |
51,912,655 |
57,173,018 |
Loss |
5,260,363 |
15 |
261 |
|
|
||||||||
|
21975 |
chr5 |
p15.2p14.3 |
13,514,464 |
18,988,928 |
Loss |
5,474,464 |
3 |
122 |
|
|
||||||||
|
21555 |
chr7 |
p22.3p22.1 |
153,644 |
6,230,285 |
Gain |
6,076,641 |
32 |
434 |
|
|
||||||||
|
21547 |
chr2 |
q24.3q31.1 |
168,702,606 |
174,842,496 |
Loss |
6,139,890 |
11 |
226 |
|
|
||||||||
|
21755 |
chr11 |
p12p11.2 |
37,540,680 |
43,940,573 |
Loss |
6,399,893 |
14 |
298 |
|
|
||||||||
|
21761 |
chr3 |
p14.1p12.3 |
70,738,914 |
77,275,908 |
Loss |
6,536,994 |
6 |
151 |
|
|
||||||||
|
22151 |
chr15 |
q11.2q13.1 |
18,809,804 |
26,194,049 |
Gain |
7,384,245 |
14 |
331 |
|
|
||||||||
|
22322 |
chr8 |
p21.3p12 |
22,954,212 |
30,630,828 |
Loss |
7,676,616 |
9 |
224 |
|
|
||||||||
|
21889 |
chr2 |
q33.1q34 |
202,901,021 |
211,366,732 |
Gain |
8,465,711 |
13 |
281 |
|
|
||||||||
|
21723 |
chr5 |
q23.1q23.3 |
121,487,477 |
130,306,377 |
Loss |
8,818,900 |
4 |
204 |
|
|
||||||||
|
22337 |
chr1 |
p36.22p36.13 |
9,476,880 |
19,436,653 |
Loss |
9,959,773 |
21 |
436 |
|
|
||||||||
|
21795 |
chr1 |
p34.2p32.3 |
41,201,837 |
55,191,500 |
Gain |
13,989,663 |
17 |
440 |
|
|
||||||||
|
20986 |
chr12 |
p13.33p12.3 |
84,918 |
17,505,135 |
Gain |
17,420,217 |
46 |
800 |
|
|
||||||||
|
21957 |
chr11 |
q23.3q25 |
116,478,434 |
134,419,382 |
Gain |
17,940,948 |
40 |
784 |
|
|
||||||||
|
21596 |
chr1 |
q25.1q32.1 |
173,519,967 |
203,663,817 |
Gain |
30,143,850 |
25 |
814 |
|
|
||||||||
|
22055 |
chr3 |
p14.1p13 |
71,164,161 |
71,958,845 |
Loss |
794,684 |
3 |
46 |
|
|
||||||||
|
21566* |
chr17 |
p13.2p13.1 |
6,081,457 |
6,904,679 |
Loss |
823,222 |
3 |
14 |
|
|
||||||||
|
21558 |
chr22 |
q13.33 |
48,567,185 |
49,517,230 |
Loss |
950,045 |
6 |
54 |
|
|
||||||||
|
21770 |
chr8 |
p23.3 |
202,505 |
1,411,517 |
Loss |
1,209,012 |
5 |
96 |
|
|
||||||||
|
22254 |
chr8 |
p23.2 |
2,604,280 |
3,966,809 |
Loss |
1,362,529 |
9 |
140 |
|
|
||||||||
|
21937 |
chr7 |
q11.23 |
72,404,049 |
73,771,409 |
Loss |
1,367,360 |
10 |
158 |
|
|
||||||||
|
21710 |
chr15 |
q13.2q13.3 |
28,741,818 |
30,186,356 |
Loss |
1,444,538 |
3 |
64 |
|
|
||||||||
|
21722 |
chr15 |
q13.2q13.3 |
28,741,818 |
30,226,376 |
Loss |
1,484,558 |
3 |
65 |
|
|
||||||||
|
21739 |
chr15 |
q13.2q13.3 |
28,741,818 |
30,226,376 |
Loss |
1,484,558 |
3 |
65 |
|
|
||||||||
|
21787 |
chr15 |
q13.2q13.3 |
28,741,818 |
30,226,376 |
Loss |
1,484,558 |
3 |
65 |
|
|
||||||||
|
21897* |
chr5 |
p15.2 |
8,511,592 |
9,888,817 |
Gain |
1,377,225 |
34 |
29 |
|
|
||||||||
|
21884 |
chrX |
q28 |
152,676,750 |
153,059,428 |
Gain |
382,678 |
3 |
44 |
|
|
||||||||
|
21592 |
chrX |
p22.33q28 |
701 |
154,888,083 |
Gain |
154,887,382 |
325 |
6888 |
|
|
||||||||
|
22087 |
chrY |
p11.32 |
262,578 |
57,715,879 |
Gain |
57,453,301 |
49 |
49 |
|
|
||||||||
|
22285 |
chrX |
p21.1 |
31,759,551 |
31,830,811 |
Loss |
71,260 |
2 |
11 |
|
|
||||||||
|
22244 |
chr22 |
q13.33 |
49,342,961 |
49,514,486 |
Loss |
171,525 |
2 |
56 |
|
|
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|
*additional alterations identified by oligonucleotide aCGH. |
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|
|
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|
Neill et al. Molecular Cytogenetics 2010 3:11 doi:10.1186/1755-8166-3-11 |
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