Figure 2.

FISH-results obtained in cases A, B and C after application of mMCB and MCB. case A: MCB probe sets 1, 19 and 20 showed the presence of two normal chromosomes 1, one normal chromosome 19 and no normal chromosome 20. Additionally a der(19)t(1;19)(q21;p13.3), a der(20)t(1;20)(q21;q11.2) and an r(20)(p11.2q12). A der(2)t(2;11) was described using MCB 11 and subtelomeric probe 2q (latter result not shown). case B: mMCB identified a reciprocal translocation t(1;16)(q31;q23) (red arrowhead), a der(5)(1;5)(q32;p13) (blue arrowhead), a der(16)t(16;1;5)(q23;q31~q32;p13) (green arrowhead) and the constitutional additional chromosome 21 (grey arrowhead). mMCB result is shown here in a three color channel depiction. case C: MCB using probe sets for chromosomes 1 and 17 confirmed the presence of a unbalanced translocation t(1;17)(q32;p13).