Figure 3.

Characterization of translocation chromosomes by metaphase FISH. The two der(15) chromosomes revealed hybridization signals for clones up to BP4 and no signal distal to BP5. Der(9) chromosome revealed hybridization signal for pDJ184n23, which is distal to BP5. A) Schematic representation of chromosomes 9, 15 and the derivative chromosomes. In panels B-F, red signals represent pcm15, a chromosome 15 centromere probe. The positions of the other clones used for FISH are shown in Figure 2A. Chromosomes 9, 15 and the derivative chromosomes are indicated in each panel. B) Green signals represent clone 770c6, which lies in proximal to BP2. C) Green signals represent clone pDJ437h9, which lies in the BP2-BP3 interval. D) Green signals represent clone pDJ9i9, a BP2-BP3 probe that lies just proximal to BP3. E) Green signals represent clone pDJ204m06, which lies between BP3-BP4. F) Green signals represent clone pDJ184n23, which lies distal to BP5.