Table 2 |
||||
|
Molecular neurocytogenetic data on accelerated aging diseases |
||||
|
Disease |
Neurocytogenetic findings |
CIN |
GIN |
References |
|
|
||||
|
Down syndrome |
Presumably 100% (?) of trisomy 21 |
NS* |
NS* |
|
|
|
||||
|
Alzheimer's diseases (AD) |
Chromosome 21-specific aneuploidy confined to degenerated brain areas |
+ |
? |
[14] |
|
|
||||
|
AD model (transfected human cells with presenelin 1 mutations) |
Acquired chromosome missegregation causing aneuploidy |
+ |
+ |
[46] |
|
|
||||
|
Ataxia telangiectasia |
Aneuploidy; chromosome breakage producing additional rearranged chromosomes (partial aneuploidy) confined to the degenerated cerebellum |
+ |
+ |
|
|
|
||||
|
*NS -- not studied |
||||
|
Yurov et al. Molecular Cytogenetics 2009 2:23 doi:10.1186/1755-8166-2-23 |
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