Research
Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?
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* Corresponding author: Leda Dalprà leda.dalpra@unimib.it
1 Department of Neuroscience and Biomedical Technologies, University of Milan-Bicocca, via Cadore 48, 20052, Monza, Italy
2 Medical Genetics Lab, Department of Clinical Pathology, HS. Gerardo, via Pergolesi 33, 20052, Monza, Italy
3 Department of Clinical Pathology, HS. Gerardo, via Pergolesi 33, 20052, Monza, Italy
4 Department of Pathology, Istituti Ospitalieri Hospital, Viale Concordia 1, 26100, Cremona, Italy
5 Medical Genetics Lab, Istituti Ospitalieri Hospital, Viale Concordia 1, 26100, Cremona, Italy
Molecular Cytogenetics 2009, 2:19 doi:10.1186/1755-8166-2-19
Published: 27 September 2009Additional files
Additional file 1:
List of BAC probes and microsatellites used in the study. Localisation and results summary of BAC probes and microsatellite used in molecular and molecular-cytogenetics analysis.
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Additional file 2:
Visual explication of possible rearrangement occurred during translocation process. The low-copy repeat/nonallelic homologous recombination can result in complex rearrangements explaining our results discrepancy.
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Additional file 3:
X inactivation analysis by chromosome territory disposition. A. Visual explication of the method used to evaluate derivative chromosome position in the nucleus. B. Image of X and der(Y) chromosome territories in interphase nuclei.
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Additional file 4:
Statistical analysis of chromosome territory (CT) and centromere distribution in interphase nuclei. A. The table summarise the statistical analysis (χ2 test) performed on the results of CT distances (X, Y and derivative Y chromosomes) in interphase nuclei. B. The table summarise the statistical analysis (χ2 test) performed on the results of X and Y centromere reciprocal distribution in interphase nuclei.
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Additional file 5:
Chromosome territory image analysis. Graphic representation of chromosome territory image analysis.
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Additional file 6:
Sequences of forward and reverse primers used in PCR reaction for SRY gene sequencing. Primer details for SRY sequencing.
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